Fourier-LSTM on the Edge: Elevating Genome Sequencing Performance on the Portable Devices

Genome sequencing has evolved from Sanger to advanced third-generation technologies, yet challenges such as limited read lengths and high costs remain. This paper introduces Fourier-LSTM, a hardware-efficient block integrating Fourier transformations with Long Short-Term Memory (LSTM) networks. This approach enhances handling long repetitive sequences and structural variations to improve nanopore sequencing accuracy. Notably, deploying Fourier-LSTM on the embedded RK3588 device significantly reduces power consumption and costs, making it ideal for real-time, portable genomic applications.