Positron Range Correction Helps Enhance the Image Quality of Cardiac⁸²Rb PET/CT

The image quality and quantitative accuracy of ⁸²Rb myocardial perfusion imaging (MPI) using PET is challenged by the extensive positron range (PR) effects, with the PR of ⁸²Rb being about 7 mm in soft tissues. This study explored the feasibility of applying postacquisition PR correction (PRC) to routine ⁸²Rb PET/CT MPI acquisitions and assessed its impact on diagnostic accuracy and image quality. <b>Methods:</b> We implemented a PRC method adjusted to ⁸²Rb into a vendor-provided reconstruction toolbox, using tissue-specific corrections for soft tissue, bone, and air/lungs. The PRC was evaluated in 2 cohorts: the first comprised 25 healthy volunteers who underwent repeated ⁸²Rb MPI within 2 wk, and the second included 66 patients with known or suspected coronary artery disease. We measured the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) for the volunteer cohort. In the patient cohort, the impact of PRC was evaluated as changes in the area under the receiver operating characteristic curve (AUC), using fractional flow reserve as the gold standard (values < 80% were considered significantly reduced). We calculated AUCs for stress and ischemic total perfusion deficits. <b>Results:</b> In the volunteer cohort, PRC-based reconstructions (standard reconstruction [STD] + PRC) demonstrated significantly improved SNR and CNR compared with STD, with median increases of 22% and 47% for SNR and CNR, respectively (<i>P</i> < 0.05). For the patient cohort, comparable AUCs were reported for STD- versus PRC-based reconstructions (stress total perfusion deficits, 0.84 vs. 0.83 [<i>P</i> = 0.49]; ischemic total perfusion deficits, 0.87 vs. 0.87 [<i>P</i> = 0.80]). <b>Conclusion:</b> PRC significantly enhances SNR and CNR compared with STD without affecting the diagnostic accuracy of the scans. Given the significantly improved image quality, PRC may be recommended for MPI using ⁸²Rb PET/CT clinical-routine-assessment interpretation of TPD.