RNF31 induces paclitaxel resistance by sustaining ALYREF cytoplasmic–nuclear shuttling in human triple‐negative breast cancer
RNF31 facilitated ALYREF-mediated PTX resistance in TNBC. RNF31 promoted ALYREF nuclear transport via IPO13 in response to PTX treatment, subsequently enhancing the export of mRNAs encoding PTX resistance-related factors, including TUBB3, STMN1, and TAU. Blocking RNF31 trapped ALYREF in the cytoplasm and induced TNBC cell death upon PTX treatment. Inhibiting RNF31 activity re-sensitized PTX-resistant TNBC to PTX treatment.
Authors
- Muwen Yang (ORCID: https://orcid.org/0000-0002-0786-7059)
- Xuwei Chen (ORCID: https://orcid.org/0000-0001-7189-5022)
- Chuyong Lin (ORCID: https://orcid.org/0000-0003-4887-5386)
- Yawei Shi (ORCID: https://orcid.org/0000-0002-2602-5383)
- Lixin He
- Boyu Chen (ORCID: https://orcid.org/0000-0002-1422-713X)
- Libing Song (ORCID: https://orcid.org/0000-0002-5315-771X)
- Xiangfu Chen
- Shuqin Dai (ORCID: https://orcid.org/0000-0003-2586-6989)
- Dongni Shi (ORCID: https://orcid.org/0000-0003-3669-2734)
- Jun Li (ORCID: https://orcid.org/0000-0002-1171-7141)
- Yue Li (ORCID: https://orcid.org/0000-0002-1949-7913)
- Weidong Wei (ORCID: https://orcid.org/0000-0001-7511-7252)
- Pinwei Deng
- Shu‐Mei Huang (ORCID: https://orcid.org/0000-0001-8323-0888)
- Lingzhi Kong
- Xingyu Jiang (ORCID: https://orcid.org/0009-0008-3043-819X)
- Rui Wang (ORCID: https://orcid.org/0009-0009-3413-940X)
Institutions
- Sun Yat-sen University (CN)
- Peking University Shenzhen Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70203
- Citations
- 7
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- Basic and Applied Basic Research Foundation of Guangdong Province