Comparative assessment of acute toxicity, wound healing and local irritant effects of dental products in in vivo experiments

Studies have been carried out to determine the pharmacological activity of new topical dental products containing betulin in in vivo experiments. The parameters of acute toxicity of dental products were determined using the Kerber method, the wound healing effect was studied on a thermal burn model. As a result of the experiments conducted, it was found that when studying the acute toxicity of dental products for topical use, it was not possible to establish LD50 indicators, since the doses of the studied drugs into the stomach of mice did not cause the death of animals. In accordance with the classification of toxicity of chemicals according to GOST 12.1.007-76, dental products for topical use are low-toxic substances. Dental products on the thermal burn model have a significantly pronounced wound healing effect. When the studied drugs were administered, no local irritant effect or manifestations of allergic reactions were observed.