A Mendelian randomization study investigating the role of sleep traits and their joint effects on the incidence of atrial fibrillation
Our study indicates that insomnia symptoms and short sleep duration are causal risk factors for AF. However, having two sleep traits in combination does not increase risk beyond the additive risk of each individual trait. This reinforces clinical and public health efforts to effectively manage insomnia symptoms and short sleep, in order to mitigate the risk of AF and improve overall cardiovascular health.
Authors
- Laxmi Bhatta (ORCID: https://orcid.org/0000-0002-8166-1470)
- Vegard Malmo (ORCID: https://orcid.org/0000-0001-5954-7594)
- Linn Beate Strand (ORCID: https://orcid.org/0000-0001-7730-0675)
- Eivind Schjelderup Skarpsno (ORCID: https://orcid.org/0000-0002-4135-0408)
- Bjørn Olav Åsvold (ORCID: https://orcid.org/0000-0003-3837-2101)
- Rebecca C. Richmond (ORCID: https://orcid.org/0000-0003-0574-5071)
- Nikhil Arora (ORCID: https://orcid.org/0000-0001-5767-5410)
- Ben Michael Brumpton (ORCID: https://orcid.org/0000-0002-3058-1059)
- Jan Pål Loennechen (ORCID: https://orcid.org/0000-0003-0492-3286)
Institutions
- Norwegian University of Science and Technology (NO)
- University of Bristol (GB)
- University of Oxford (GB)
- St Olav's University Hospital (NO)
- Health Biomed (China) (CN)
- Oxford BioMedica (United Kingdom) (GB)
- MRC Epidemiology Unit (GB)
Publication Details
- Journal
- European Journal of Preventive Cardiology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1093/eurjpc/zwaf062
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- Norges Teknisk-Naturvitenskapelige Universitet
- Helse Midt-Norge
- St. Olavs Hospital Universitetssykehuset i Trondheim
- Nasjonalforeningen for Folkehelsen
- Fakultet for medisin og helsevitenskap, Norges Teknisk-Naturvitenskapelige Universitet
- Faculty of Medicine and Health, University of Sydney
- Norwegian Institute of Public Health