Highly Efficient Synthesis of 1,3,5-Oxadiazinan-4-one and 5-Methyl-1,3,5-triazinan-2-one Derivatives of Benzimidazolyl Pyrimidine and Their Activity Analysis through Docking Studies
4-(1H-Benzimidazol-2-yl)-6-phenylpyrimidin-2-yl-substituted 1,3,5-oxadiazinan-4-one and 5-methyl-1,3,5-triazinan-2-one derivatives were synthesized from N-[4-(1H-benzimidazol-2-yl)-6-phenylpyrimidin-2-yl]-N′-aryl ureas, and their structure was confirmed by NMR and mass spectroscopic techniques. Some of the synthesized derivatives were analyzed for their binding affinity for EGFR through molecular docking studies.
Authors
- Srinivasa Reddy Bireddy (ORCID: https://orcid.org/0000-0003-0769-0844)
- Bhaskar Pittala
- L. Eppakayala
- S. Kethireddy
- S. Patolla
Institutions
- Goethe-Institute United Kingdom (GB)
- Gandhi Medical College & Hospital (IN)
- Bharat Heavy Electricals (India) (IN)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070428024120194
- Primary Topic
- Synthesis and Characterization of Heterocyclic Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00