Synthesis of the C1–C9 Block of Epothilone D Analogue

(2R,5R,6S,7S,9E)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,5,7-tetramethyl-4-oxo-6-[(triethylsilyl)oxy]undec-9-enoic acid has been synthesized as the C1–C9 block necessary for the subsequent incorporation into the structure of a desired epothilone D analogue.

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Publication Details

Journal
Russian Journal of Organic Chemistry
Published
2024-12-01
DOI
https://doi.org/10.1134/s1070428024120091
Primary Topic
Cancer Treatment and Pharmacology
Type
article
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article

Synthesis of the C1–C9 Block of Epothilone D Analogue

М. С. Мифтахов, G. R. Sunagatullina
Russian Journal of Organic Chemistry
Cancer Treatment and Pharmacology
article

Synthesis of the C1–C9 Block of Epothilone D Analogue

М. С. Мифтахов, G. R. Sunagatullina
article en

Abstract

(2R,5R,6S,7S,9E)-2-{[tert-Butyl(dimethyl)silyl]oxy}-3,3,5,7-tetramethyl-4-oxo-6-[(triethylsilyl)oxy]undec-9-enoic acid has been synthesized as the C1–C9 block necessary for the subsequent incorporation into the structure of a desired epothilone D analogue.

Russian Journal of Organic ChemistryVol. 60(12)
Ufa Institute of Chemistry (RU)
Openalex Percentile: Top 58%
Cancer Treatment and Pharmacology
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Synthesis of the C1–C9 Block of Epothilone D Analogue — М. С. Мифтахов, G. R. Sunagatullina · Russian Journal of Organic Chemistry (2024) | TGRS Research Map | TGRS