HSPG2 could promote normal haematopoiesis in acute myeloid leukaemia patients after complete remission by repairing bone marrow endothelial progenitor cells
The HSPG2 level in the BM EPCs of AML-CR patients was decreased, which was related to the reduced BM EPC function. HSPG2 knockdown or Ara-C intervention reduced the HSPG2 level and led to BM EPC dysfunction, which could be restored by HSPG2 treatment in vitro. HSPG2 treatment restored the BM EPC function of AML-CR patients without affecting their leukaemia cell-supporting ability.
Authors
- Hao Jiang (ORCID: https://orcid.org/0000-0003-2337-2539)
- Xiao‐Jun Huang (ORCID: https://orcid.org/0000-0002-2145-6643)
- Yuan Kong (ORCID: https://orcid.org/0000-0001-5594-2642)
- Qian Jiang (ORCID: https://orcid.org/0000-0001-6882-1305)
- Zhenkun Wang (ORCID: https://orcid.org/0000-0003-4894-0029)
- Chen‐Yuan Li (ORCID: https://orcid.org/0000-0002-0048-5904)
- Min Shen (ORCID: https://orcid.org/0000-0003-1912-126X)
- Dandan Chen (ORCID: https://orcid.org/0000-0003-4224-812X)
- Xiaohui Zhang (ORCID: https://orcid.org/0000-0003-0245-6792)
- Tong Xing (ORCID: https://orcid.org/0000-0003-1561-4614)
- Yu Wang (ORCID: https://orcid.org/0000-0001-6351-6467)
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/ctm2.70220
- Citations
- 1
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality
- Peking University
- Peking University People's Hospital
- National Key Research and Development Program of China