Extracellular Vesicles From Dental Pulp Cells Promote Osteogenic Differentiation in Periodontal Ligament Cells
HOXA9 from DPCs-derived EVs promoted PDLC osteogenic differentiation by activating the PI3K/AKT pathway through promoting H3K27ac enrichment in the FLI1 enhancer region and upregulating FLI1. Our study identified a previously unknown mechanism that HOXA9/FLI1 signaling axis participates in the processes of EVs derived from DPCs to treat bone tissue injury. Our research presents a theoretical basis for using EVs derived from DPCs to treat bone tissue injury.
Authors
- Haitao Liu (ORCID: https://orcid.org/0000-0003-3628-5688)
- Yingying Li (ORCID: https://orcid.org/0000-0002-0237-6824)
- Jie Hao (ORCID: https://orcid.org/0000-0002-7739-1850)
- Limei Li
- Fenglan Li (ORCID: https://orcid.org/0000-0002-0090-4611)
Institutions
- Shanxi Medical University (CN)
- Shanxi Provincial People’s Hospital (CN)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1111/jre.13390
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- China Postdoctoral Science Foundation