Longitudinal maternal glycemia during pregnancy and placental epigenetic age acceleration
Elevated glucose, HbA1c, and insulin cumulative levels throughout pregnancy were associated with lower PAA in Black and Asian/Pacific Islander women. Placental epigenetic aging may be altered by maternal elevated glycemia and may in part underlie early programming of health outcomes in pregnancy and childhood health outcomes.
Authors
- Fasil Tekola‐Ayele (ORCID: https://orcid.org/0000-0003-4194-9370)
- Jagteshwar Grewal (ORCID: https://orcid.org/0000-0002-0141-4876)
- Prabhavi Wijesiriwardhana
- Richard J. Biedrzycki (ORCID: https://orcid.org/0000-0003-1994-2295)
- Tesfa Dejenie Habtewold (ORCID: https://orcid.org/0000-0003-4476-518X)
- Katherine L. Grantz (ORCID: https://orcid.org/0000-0003-0276-8534)
- Cuilin Zhang
Institutions
- National Institutes of Health (US)
- Harvard University (US)
- National University of Singapore (SG)
- Université Bourgogne Franche-Comté (FR)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13148-025-01825-z
- Citations
- 3
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 6.17
Funders
- Northwestern University
- University of South Carolina
- Australian Government
- National Institutes of Health
- University of California, Irvine
- NIH Office of the Director
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- National Institute on Minority Health and Health Disparities
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NHLBI Division of Intramural Research