Longitudinal associations of dietary intake with fatigue in colorectal cancer survivors up to 1 year post-treatment, and the potential mediating role of the kynurenine pathway
Our findings suggest that carbohydrate intake is associated with greater fatigue, while protein and fat intake are associated with lower fatigue in CRC survivors up to 1 year post-treatment. While all KP metabolites simultaneously did not significantly mediate associations between diet and fatigue in our population, the KA/QA ratio and HKr were significant mediators in several diet-fatigue associations. These results should be repeated in larger observational studies.
Authors
- Stefanie Brezina (ORCID: https://orcid.org/0000-0001-5238-6900)
- Adrian McCann (ORCID: https://orcid.org/0000-0002-5728-5321)
- Cornelia M. Ulrich (ORCID: https://orcid.org/0000-0001-7641-059X)
- Martijn J.L. Bours (ORCID: https://orcid.org/0000-0002-5558-1258)
- Maryska L.G. Janssen‐Heijnen (ORCID: https://orcid.org/0000-0003-3575-6070)
- Per Magne Ueland (ORCID: https://orcid.org/0000-0002-1903-0571)
- Matty P. Weijenberg (ORCID: https://orcid.org/0000-0003-1695-4768)
- Daniëlle D. B. Holthuijsen (ORCID: https://orcid.org/0000-0002-4352-6198)
- Stéphanie O. Breukink (ORCID: https://orcid.org/0000-0002-5445-4011)
- Biljana Gigic (ORCID: https://orcid.org/0000-0002-8085-2072)
- Joop Konsten (ORCID: https://orcid.org/0000-0002-8803-1914)
- Judith J. M. Rijnhart (ORCID: https://orcid.org/0000-0002-1046-3741)
- Eric T.P. Keulen (ORCID: https://orcid.org/0000-0001-6666-8773)
- Simone J. P. M. Eussen (ORCID: https://orcid.org/0000-0003-0559-6838)
- Eline H. van Roekel (ORCID: https://orcid.org/0000-0002-9402-2029)
Institutions
- University of Utah (US)
- Heidelberg University (DE)
- University of South Florida (US)
- Maastricht University Medical Centre (NL)
- Huntsman Cancer Institute (US)
- University Hospital Heidelberg (DE)
- Maastricht University (NL)
- Comprehensive Cancer Center Vienna (AT)
- VieCuri Medisch Centrum (NL)
- Zuyderland Medisch Centrum (NL)
- Bevital (Norway) (NO)
- Maastro Clinic (NL)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.bbi.2025.02.003
- Primary Topic
- Cancer survivorship and care
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health Foundation Limburg
- Universiteit Maastricht
- Bundesministerium für Bildung und Forschung
- KWF Kankerbestrijding
- World Cancer Research Fund
- National Cancer Institute