Mapping chromatin remodelling in glioblastoma identifies epigenetic regulation of key molecular pathways and novel druggable targets
We show epigenetic regulation of the expression of genes and related signalling pathways contributing to glioblastoma development. We also identify novel epigenetically regulated druggable target genes on a patient-specific level, including SMOX and GABBR2.
Authors
- Silvia Marino (ORCID: https://orcid.org/0000-0002-9612-2883)
- Charles A. Mein (ORCID: https://orcid.org/0000-0003-0811-9658)
- Nicola Pomella (ORCID: https://orcid.org/0000-0003-0028-4878)
- Nicolae Radu Zabet (ORCID: https://orcid.org/0000-0001-9964-6271)
- James R. Boot (ORCID: https://orcid.org/0000-0002-5629-5026)
- Weiwei Jin (ORCID: https://orcid.org/0000-0001-9320-9628)
- Claire Vinel (ORCID: https://orcid.org/0000-0003-3329-321X)
- Alexandra Hadaway
Institutions
- Queen Mary University of London (GB)
- Brain Tumour Research (GB)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12915-025-02127-9
- Citations
- 7
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Barts Charity
- Cancer Research UK
- Brain Tumour Charity
- Brain Tumour Research