Predictive values of prognostic nutritional index and systemic immüne- inflammatory index in the follow-up newborns of preeclamptic mothers

<b>Background</b>: Preeclampsia (PE) is among the causes of serious morbidity and mortality for the mother and fetus. The most common consequences of intrauterine hypoxemia in the newborn are intrauterine growth retardation (IUGR), premature labor, respiratory distress syndrome (RDS), necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), and perinatal death. The systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI), which is used as an indicator of inflammation, can be used to examine the effect of the immune status of babies of PE mothers on their prognosis.<b>Methods</b>: A retrospective cohort study was conducted on 148 newborns of PE mothers who received treatment in our NICU between November 2022 and July 2024. Hematological indices including neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, SII, and PNI were calculated for all patients. Subgroups were created for complications and analyses were performed.<b>Results</b>: For all preeclamptic mothers' babies, the mean SII and PNI were 387.69 ± 348.13 and 49.08 ± 7.59, respectively. The SII for prematurity produced an area under the curveReceiver operating characteristic (ROC) of 0.76 (0.59-0.92) (88.4% sensitivity, 70% specificity). The PNI for prematurity produced an area under the curve ROC of 0.72 (0.57-0.86) (63% sensitivity, 70% specificity). That was found that the SII has more sensitivity than the PNI for detecting prematurity in preeclamptic mothers' babies. Low PNI and SII were independent predictors of mortality (<i>p</i> < 0.01).<b>Conclusion</b>: We found that it is significant for SII and NLR to be low at the time of admission to predict mortality in infants of preeclamptic mothers.