Organic Base-Catalyzed Cascade Reaction of CF<sub>3</sub>–Iminopropargylic Alcohols with Carboxylic Acids: an Approach to β-CF<sub>3</sub> β-Aminoenones

A novel approach to the synthesis of β-CF<sub>3</sub> β-aminoenones by the organic amine base-catalyzed reaction of CF<sub>3</sub>-iminopropargylic alcohols with carboxylic acids is reported. The advantages of the protocol are the ease of operation, available starting materials, and simple tertiary amine catalysts.

Authors

Igor А. Ushakov (ORCID: https://orcid.org/0000-0003-0176-1699)
O. G. Volostnykh
Olesya A. Shemyakina (ORCID: https://orcid.org/0000-0001-7371-3982)
А. В. Степанов (ORCID: https://orcid.org/0000-0002-0771-7261)
Ruslan S. Shulgin (ORCID: https://orcid.org/0000-0003-2229-6589)

Institutions

A.E. Favorsky Irkutsk Institute of Chemistry (RU)

Publication Details

Journal: The Journal of Organic Chemistry
Published: 2025-02-06
DOI: https://doi.org/10.1021/acs.joc.4c02959
Citations: 2
Primary Topic: Fluorine in Organic Chemistry
Type: article
Field-Weighted Citation Impact: 1.58

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article

Organic Base-Catalyzed Cascade Reaction of CF₃–Iminopropargylic Alcohols with Carboxylic Acids: an Approach to β-CF₃ β-Aminoenones

Igor А. Ushakov, O. G. Volostnykh, Olesya A. Shemyakina, А. В. Степанов et al.

Feb 6, 2025

2 citations

The Journal of Organic Chemistry

Fluorine in Organic Chemistry

1.58

article

Organic Base-Catalyzed Cascade Reaction of CF₃–Iminopropargylic Alcohols with Carboxylic Acids: an Approach to β-CF₃ β-Aminoenones

Igor А. Ushakov, O. G. Volostnykh, Olesya A. Shemyakina, А. В. Степанов, Ruslan S. Shulgin

February 6, 2025article en

2 citations

Abstract

A novel approach to the synthesis of β-CF<sub>3</sub> β-aminoenones by the organic amine base-catalyzed reaction of CF<sub>3</sub>-iminopropargylic alcohols with carboxylic acids is reported. The advantages of the protocol are the ease of operation, available starting materials, and simple tertiary amine catalysts.

The Journal of Organic ChemistryVol. 90(7)

A.E. Favorsky Irkutsk Institute of Chemistry (RU)

Clean water and sanitation

Openalex Percentile: Top 19%

Fluorine in Organic Chemistry

1.58

DOI Source OpenAlex

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