Awafung Emmanuel Adie

The exploration of electrospun nanofibers has gained significant attention in wound healing due to their unique structural properties and potential to enhance therapeutic efficacy. This review examines the development and application of electrospun nanofibers, focusing on their antibacterial properties and biocompatibility, which are essential for effective wound management. Electrospinning techniques enable the production of nanofibers with high surface-area-to-volume ratios, tunable porosity, and controlled release profiles of therapeutic agents, making them ideal for wound dressings. We explore various biopolymers and synthetic polymers used in electrospun nanofiber fabrication, emphasizing their contributions to antibacterial effects and biocompatibility. The incorporation of antimicrobial agents, such as silver nanoparticles and essential oils, enhances infection prevention and promotes healing. Additionally, challenges related to the scalability of electrospinning processes and the need for standardized evaluation methods are discussed. The review also highlights the influence of nanofiber architecture such as fiber diameter, alignment, and surface modifications on cellular response and tissue integration. The findings underscore the potential of electrospun nanofibers to not only serve as passive wound dressings but also actively facilitate healing through antibacterial action and favorable biological interactions. Future research should focus on optimizing fabrication techniques, enhancing functional properties, and conducting in vivo studies to fully realize the clinical potential of these materials in wound care applications. Keywords: Electrospun, nanofibers, wound healing, antibacterial and biocompatibility