α-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease
αSyn-SAA positivity and faster seed amplification are associated with a greater risk of developing PD in at-risk individuals and may aid in predicting phenoconversion.
Authors
- Michael C. Brumm (ORCID: https://orcid.org/0000-0002-3173-9989)
- Ben Shifflett (ORCID: https://orcid.org/0000-0002-6758-1220)
- Luis Concha‐Marambio (ORCID: https://orcid.org/0000-0002-9454-8389)
- Yihua Ma (ORCID: https://orcid.org/0000-0002-5664-8178)
- David G. Coughlin (ORCID: https://orcid.org/0000-0003-4111-0102)
- Kathleen L. Poston (ORCID: https://orcid.org/0000-0003-3424-7143)
- Douglas R Galasko (ORCID: https://orcid.org/0000-0001-6195-3241)
- Andrew D. Siderowf (ORCID: https://orcid.org/0000-0002-1750-7698)
- Carly M. Farris (ORCID: https://orcid.org/0000-0002-8277-8531)
- Brit Mollenhauer (ORCID: https://orcid.org/0000-0001-8437-3645)
- Claudio Soto
- Steven D. Edland (ORCID: https://orcid.org/0000-0002-1153-7335)
- Kenneth Marek (ORCID: https://orcid.org/0000-0002-4197-5627)
Institutions
- University of Iowa (US)
- University of California San Diego (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Institute for Neurodegenerative Disorders (US)
- Amprion (United States) (US)
- Universitätsmedizin Göttingen (DE)
- Paracelsus Elena Klinik Kassel (DE)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1212/wnl.0000000000210279
- Citations
- 21
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 29.17
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Jazz Pharmaceuticals
- Neurocrine Biosciences
- Verily Life Sciences
- Voyager Therapeutics
- Servier
- H. Lundbeck A/S
- Sun Pharma
- Genentech
- Allergan
- Avid Radiopharmaceuticals