Thiotepa-Induced Toxicity: A Clinical Mimic of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Featuring Severe Mucositis, Diffuse Dusky Discoloration, and Skin Sloughing
This case highlights the diagnostic challenge of distinguishing thiotepa-induced TEC from SJS/TEN in post-transplant patients. Recognizing the characteristic involvement of intertriginous areas and eccrine gland necrosis in TEC is critical for accurate diagnosis and management. Awareness of this potential complication in patients receiving thiotepa is essential to avoid misdiagnosis and inappropriate treatment.
Authors
- Robert Phelps (ORCID: https://orcid.org/0000-0002-9010-6612)
- Ruwaida Ben Musa (ORCID: https://orcid.org/0000-0002-0658-6941)
- Omar P. Sangüeza
- Dinesh Pradhan (ORCID: https://orcid.org/0000-0001-8591-1601)
- Nada Shaker (ORCID: https://orcid.org/0000-0001-6145-256X)
- George Niedt
- Rituja Bhowmik
Institutions
- University of California, San Francisco (US)
- Wake Forest University (US)
- University of Nebraska Medical Center (US)
- University of Missouri (US)
- University of California, Berkeley (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- American Journal of Dermatopathology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1097/dad.0000000000002923
- Citations
- 2
- Primary Topic
- Chemotherapy-related skin toxicity
- Type
- article
- Field-Weighted Citation Impact
- 4.01