Comparison of the IHC Expression of p16, p53, and MIB-1 in Extragenital Skin Bowenoid Lesions With High- and Low- Chronic Sun Damage
P16 and p53 expression may be less frequent in bowenoid lesions than previously described. Histopathological features like basal layer and adnexal or follicular involvement may not differentiate H-CSD from low-chronic sun damage lesions or Bowen disease from bowenoid actinic keratosis. Variations in p16, p53, and MIB-1 staining could indicate different dysplasia pathways, although further studies are needed to clarify their prognostic significance.
Authors
- Alba Navarro‐Bielsa (ORCID: https://orcid.org/0000-0003-1171-6007)
- Laura Taboada Paz (ORCID: https://orcid.org/0000-0002-0892-2355)
- José Manuel Suárez Peñaranda (ORCID: https://orcid.org/0000-0003-4033-3638)
- María Eugenia Gil-Pallares (ORCID: https://orcid.org/0000-0003-1749-2331)
- Pedro Gil‐Pallares (ORCID: https://orcid.org/0000-0001-8469-1942)
- Olalla Figueroa‐Silva (ORCID: https://orcid.org/0000-0003-1905-5039)
Institutions
- Universidade de Santiago de Compostela (ES)
- Universidad de Zaragoza (ES)
- Board of the Swiss Federal Institutes of Technology (CH)
- ETH Zurich (CH)
- Complejo Hospitalario Universitario de Santiago (ES)
- Hospital Universitario Miguel Servet (ES)
Publication Details
- Journal
- American Journal of Dermatopathology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1097/dad.0000000000002939
- Citations
- 1
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.35