<scp>ALS</scp> plasma biomarkers reveal neurofilament and <scp>pTau</scp> correlate with disease onset and progression
We confirm previous reports showing elevated pTau181 in ALS plasma and show elevation of other phosphorylated tau forms, pTau217 and pTau231, typically observed in Alzheimer's disease. We provide preliminary data showing the detection and elevation of pTDP-43-409/410 in a subset of ALS samples compared to healthy controls. Neurofilament and tau levels are highly correlated suggesting their elevation may reflect a common pathology and disease state. Total and phosphorylated tau are correlated with multiple disease measures, such as ALS duration, ALSFRS-R, and site of onset.
Authors
- C. Han (ORCID: https://orcid.org/0000-0002-2007-3640)
- Zachary T. McEachin (ORCID: https://orcid.org/0000-0002-2369-8726)
- Eleanor V. Thomas (ORCID: https://orcid.org/0000-0003-2227-884X)
- Jonathan D. Glass (ORCID: https://orcid.org/0000-0002-3295-4971)
- Jennifer Taylor (ORCID: https://orcid.org/0000-0002-1929-4454)
- Yingjie Li (ORCID: https://orcid.org/0009-0004-1499-4613)
- Woo Jae Kim
- Nicholas T. Seyfried
- C. Fournier
- Marla Gearing
Institutions
- Emory University (US)
- University of Chicago (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1002/acn3.70001
- Citations
- 13
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 18.06
Funders
- American Academy of Neurology
- National Institutes of Health
- NIH Clinical Center