The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties

Tissue maintenance is underpinned by resident stem cells whose activity is modulated by microenvironmental cues. Using Drosophila as a simple model to identify regulators of stem cell behaviour and survival in vivo, we have identified novel connections between the conserved transmembrane proteoglycan Syndecan, nuclear properties and stem cell function. In the Drosophila midgut, Syndecan depletion in intestinal stem cells results in their loss from the tissue, impairing tissue renewal. At the cellular level, Syndecan depletion alters cell and nuclear shape, and causes nuclear lamina invaginations and DNA damage. In a second tissue, the developing Drosophila brain, live imaging revealed that Syndecan depletion in neural stem cells results in nuclear envelope remodelling defects which arise upon cell division. Our findings reveal a new role for Syndecan in the maintenance of nuclear properties in diverse stem cell types.

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Publication Details

Journal
PLoS Genetics
Published
2025-02-06
DOI
https://doi.org/10.1371/journal.pgen.1011586
Citations
1
Primary Topic
Invertebrate Immune Response Mechanisms
Type
article
Field-Weighted Citation Impact
0.80

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article

The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties

Golnar Kolahgar, Tamsin J. Samuels, Buffy L. Eldridge-Thomas, Jérôme Bohère et al.
1 citations
PLoS Genetics
Invertebrate Immune Response Mechanisms
0.80
article

The transmembrane protein Syndecan is required for stem cell survival and maintenance of their nuclear properties

Golnar Kolahgar, Tamsin J. Samuels, Buffy L. Eldridge-Thomas, Jérôme Bohère, Chantal Roubinet, Felipe Karam Teixeira, Alexandre Barthelemy
article en
1 citations

Abstract

Tissue maintenance is underpinned by resident stem cells whose activity is modulated by microenvironmental cues. Using Drosophila as a simple model to identify regulators of stem cell behaviour and survival in vivo, we have identified novel connections between the conserved transmembrane proteoglycan Syndecan, nuclear properties and stem cell function. In the Drosophila midgut, Syndecan depletion in intestinal stem cells results in their loss from the tissue, impairing tissue renewal. At the cellular level, Syndecan depletion alters cell and nuclear shape, and causes nuclear lamina invaginations and DNA damage. In a second tissue, the developing Drosophila brain, live imaging revealed that Syndecan depletion in neural stem cells results in nuclear envelope remodelling defects which arise upon cell division. Our findings reveal a new role for Syndecan in the maintenance of nuclear properties in diverse stem cell types.

PLoS GeneticsVol. 21(2)
Centre National de la Recherche Scientifique (FR), Inserm (FR), University of Cambridge (GB), Institut de génétique et de développement de Rennes (FR), Université de Rennes (FR)
Wellcome, Wellcome Trust, Cancer Research UK, University of Cambridge, European Commission, Human Frontier Science Program, Agence Nationale de la Recherche, Directorate for Biological Sciences, HORIZON EUROPE Marie Sklodowska-Curie Actions, CHIST-ERA
Openalex Percentile: Top 31%
Invertebrate Immune Response Mechanisms
0.80
DOIOpen Access PDFOpenAlex
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