Synthesis and Evaluation of Neurotropic Activity of New Terahydropyridazin-3-one Derivatives
4-Aryl-4-oxo-2-(1,2-substituted 1H-indol-3-yl)butanoic acids reacted with hydrazine to give 6-aryl-4-(1,2-substituted 1H-indol-3-yl)-2,3,4,5-tetrahydropyridazin-3-ones, whereas heterocyclization of structurally related 4-aryl-4-oxo-2-hetarylbutanoic acids under similar conditions was accompanied by elimination of the azole moiety, leading to the formation of 6-aryl-2,3-dihydropyridazin-3-ones. Study of neurotropic activity of the new tetrahydropyridazinone derivatives revealed anxiolytic effect of all compounds.
Authors
- H. А. Panosyan (ORCID: https://orcid.org/0000-0001-8311-6276)
- R. Dzh. Khachikyan (ORCID: https://orcid.org/0009-0006-2014-7861)
- R. G. Paronikyan (ORCID: https://orcid.org/0000-0002-3845-6324)
- Z. G. Hovakimyan (ORCID: https://orcid.org/0009-0000-1604-5834)
- L. S. Mirzoyan (ORCID: https://orcid.org/0009-0003-4915-9805)
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
- National Academy of Sciences of Armenia (AM)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070428024120030
- Primary Topic
- Phenothiazines and Benzothiazines Synthesis and Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00