Synthesis and Biological Activity of 4-Amino-1,3,5-triaryl-1H-pyrrol-2(5H)-ones
A series of 4-amino-1,3,5-triaryl-1H-pyrrol-2(5H)-ones have been synthesized by acylation of arylacetonitriles with arylacetyl chlorides, followed by intramolecular cyclization in the presence of potassium hydroxide. The synthesized compounds have been evaluated for their antibacterial and antitumor activities; among them, derivatives containing alkyl and alkoxy groups in the aryl fragments at positions 1, 3, and 5 of the pyrrole ring turned out to be the most active.
Authors
- G. K. Harutyunyan (ORCID: https://orcid.org/0009-0001-8360-6176)
- R. E. Muradyan (ORCID: https://orcid.org/0000-0002-4110-9454)
- S. P. Gasparyan (ORCID: https://orcid.org/0000-0003-2341-724X)
- H. M. Stepanyan (ORCID: https://orcid.org/0000-0001-7236-5947)
- M. V. Aleksanyan
Institutions
- Institute of Fine Organic Chemistry of Scientific - Technological Center of Organic and Pharmaceutical Chemistry (AM)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1134/s1070428024120121
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00