Harnessing NLP and Deep Learning to Decode Disease–Gene Interactions in Lung Cancer

Lung cancer remains a critical global health challenge, necessitating advanced predictive models to enhance diagnostic and prognostic accuracy. This study employs natural language processing (NLP) and deep learning to advance personalized lung cancer prognosis and treatment response prediction. Using a synthetic dataset, our novel neural network model integrates clinical data with patient narratives to extract meaningful insights, correlating patient transcripts with existing datasets. The model interprets lung cancer histology types, gene sets, and genetic mutations, achieving 85% accuracy in predicting treatment responses, with a sensitivity of 0.88 and specificity of 0.83. By merging clinical and transcript-based data, this research provides clinicians with a reliable tool to support personalized medicine and informed decision-making. The results highlight the potential of AI-driven approaches to improve disease-gene association analysis, paving the way for innovative computational methodologies in lung cancer research.