Interleukin-37 attenuates aortic valve lesions by inhibiting <i>N</i>6-methyladenosine-mediated interleukin-1 receptor-associated kinase M degradation
Our findings confirm that inflammation and epigenetic modifications synergistically regulate IRAK-M expression. Moreover, IRAK-M represents a potential target for mitigating aortic valve calcification. Meanwhile, IL-37 exhibited inhibitory effects on CAVD development both in vivo and in vitro, giving us hope that CAVD can be treated with drugs rather than surgery.
Authors
- Dingli Xu
- Qingchun Zeng (ORCID: https://orcid.org/0000-0001-7665-8237)
- Dongtu Hu
- Yangchao Chen (ORCID: https://orcid.org/0000-0002-0249-3414)
- Hao Ren (ORCID: https://orcid.org/0000-0002-0094-5026)
- Minhui Xu (ORCID: https://orcid.org/0000-0001-6565-3174)
- Rong Huang (ORCID: https://orcid.org/0000-0002-4062-717X)
- Gaopeng Xian (ORCID: https://orcid.org/0000-0003-3121-8347)
Institutions
- Boston University (US)
- Ministry of Education of the People's Republic of China (CN)
- Chinese University of Hong Kong (HK)
- Nanfang Hospital (CN)
- Guangzhou Regenerative Medicine and Health Guangdong Laboratory (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1093/cvr/cvaf012
- Citations
- 5
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 4.03