Senolytic Treatment Alleviates Corneal Allograft Rejection Through Upregulation of Angiotensin-Converting Enzyme 2 (ACE2)
These findings highlight transplantation stress-induced senescence as a pivotal pathogenic factor in corneal allograft rejection. Senolytic therapy emerges as a potential novel strategy to mitigate transplant rejection and improve corneal allograft survival.
Authors
- Chao Wei (ORCID: https://orcid.org/0000-0003-1581-8377)
- Qingjun Zhou (ORCID: https://orcid.org/0000-0002-7770-9275)
- Hao Chi (ORCID: https://orcid.org/0000-0001-6934-3966)
- Fanxing Zeng (ORCID: https://orcid.org/0000-0003-1306-5578)
- Yaoyao Yu
- Xiaofei Bai
- Lingling Yang (ORCID: https://orcid.org/0000-0003-1149-3237)
- Xiaolei Wang (ORCID: https://orcid.org/0000-0001-6886-0312)
- Peng Peng (ORCID: https://orcid.org/0009-0002-7993-8001)
- Ting Zhang (ORCID: https://orcid.org/0000-0002-8328-8200)
- Weiyun Shi
- Wenhui Yin (ORCID: https://orcid.org/0009-0005-6444-4182)
- Li Ma (ORCID: https://orcid.org/0009-0008-1363-6469)
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- ORCID (US)
- Shandong Eye Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1167/iovs.66.2.15
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32