Alzheimer Disease Blood Biomarkers and Cognition Among Individuals With Diabetes and Overweight or Obesity
In this study of participants with T2D and overweight or obesity, increasing plasma NfL and GFAP levels over time, but not Aβ42/40 or pTau-181 levels, were associated with cognitive decline and incident cognitive impairment. These results suggest that plasma NfL and GFAP may be important biomarkers of cognitive change among this patient population.
Authors
- Doris Molina-Henry
- Joni K. Evans (ORCID: https://orcid.org/0000-0001-5794-4326)
- José A. Luchsinger (ORCID: https://orcid.org/0000-0002-5886-3648)
- Rebecca H. Neiberg (ORCID: https://orcid.org/0000-0003-0719-6520)
- Heather M. Shappell (ORCID: https://orcid.org/0000-0003-2409-6388)
- Kathleen M. Hayden (ORCID: https://orcid.org/0000-0002-7745-3513)
- Owen Carmichael (ORCID: https://orcid.org/0000-0002-0576-0047)
- Bonnie C. Sachs (ORCID: https://orcid.org/0000-0002-9352-7033)
- Stephen R. Rapp (ORCID: https://orcid.org/0000-0002-9766-3104)
- Mark A. Espeland (ORCID: https://orcid.org/0000-0002-3711-1949)
- Michelle M. Mielke (ORCID: https://orcid.org/0000-0001-7177-1185)
- Jingzhong Ding
- Santica M. Marcovina
- Karen Johnson
Institutions
- Pennington Biomedical Research Center (US)
- University of Southern California (US)
- Medpace (United States) (US)
- University of Tennessee Health Science Center (US)
- Winston-Salem State University (US)
- Columbia University Irving Medical Center (US)
- Imaging Center (US)
- Wake Forest University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1001/jamanetworkopen.2024.58149
- Citations
- 15
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 22.07