CDK1 mediates the metabolic regulation of DNA double-strand break repair in metaphase II oocytes
In summary, MII oocytes exhibit high heterogeneity in DSB repair, which is regulated by both metabolic factors and CDK1 activity. These results not only expand our understanding of oocyte DSB repair but also contribute to the modification of in vitro maturation medium for oocytes.
Authors
- Tian-Jin Xia
- Jun‐Yu Ma (ORCID: https://orcid.org/0000-0002-3339-7863)
- Xiao-Guohui Zhang
- Qin Zhang (ORCID: https://orcid.org/0000-0002-6121-6513)
- Xiang‐Hong Ou (ORCID: https://orcid.org/0000-0001-9047-1612)
- Shen Yin (ORCID: https://orcid.org/0000-0003-4792-7885)
- Juan Chen (ORCID: https://orcid.org/0000-0001-7515-5072)
- Sen Li (ORCID: https://orcid.org/0000-0001-8765-3992)
- Feng-Yun Xie
- Qing-Yuan Sun
Institutions
- Qingdao Agricultural University (CN)
- Jinan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12915-025-02142-w
- Citations
- 3
- Primary Topic
- DNA Repair Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- Key Technologies Research and Development Program