Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia
In vitro and in vivo experiments verified that H. pylori SlyD enhances TPT1 stability through hnRNPK, leading to OCT1-mediated transcriptional activation of CDX2 and the initiation of the GIM process. Our study offers novel perspectives on the pathogenesis of H. pylori-related gastric precancerous conditions.
Authors
- Yuehua Gong (ORCID: https://orcid.org/0000-0002-0146-2165)
- Chuxuan Ni
- Shuwen Zheng (ORCID: https://orcid.org/0009-0006-7874-5477)
- Moye Chen (ORCID: https://orcid.org/0000-0002-8192-4306)
- X. Sun (ORCID: https://orcid.org/0000-0003-4409-4574)
- Yuan Yuan (ORCID: https://orcid.org/0000-0002-7394-9036)
- Lu Wang (ORCID: https://orcid.org/0000-0001-8412-2985)
- Yingying Wang (ORCID: https://orcid.org/0000-0003-1397-3058)
- Rui Guo (ORCID: https://orcid.org/0000-0001-8684-1414)
- Jijun Chen (ORCID: https://orcid.org/0009-0006-1567-4237)
- Xunan Qiu
- Yunen Liu (ORCID: https://orcid.org/0000-0001-8761-2402)
Institutions
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12916-025-03911-8
- Citations
- 4
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 8.03
Funders
- National Natural Science Foundation of China