Intra-Tumoral CD8+:CD3+ Lymphocyte Density Ratio in Appendix Cancer Is a Tumor Volume- and Grade-Independent Predictor of Survival
This study highlights the diverse immune microenvironment in AC, with immune infiltration patterns correlating with tumor grade and histologic subtype. The CD8+:CD3+ ratio is a potential prognostic biomarker for patient stratification, underscoring its clinical significance. Future studies should expand immune biomarker panels and explore immunomodulatory therapies for lymphocyte-rich AC subsets.
Authors
- Ashten N. Omstead
- Ali H. Zaidi (ORCID: https://orcid.org/0000-0002-5463-2252)
- Christopher Sherry
- David L. Bartlett (ORCID: https://orcid.org/0000-0003-3099-2613)
- William A. LaFramboise (ORCID: https://orcid.org/0000-0002-6024-810X)
- Neda Dadgar (ORCID: https://orcid.org/0000-0003-3220-7148)
- Chelsea Knotts (ORCID: https://orcid.org/0000-0002-9727-9030)
- Patrick L. Wagner (ORCID: https://orcid.org/0009-0004-3935-5316)
- Catherine R Lewis (ORCID: https://orcid.org/0000-0002-8434-178X)
- Kunhong Xiao (ORCID: https://orcid.org/0000-0002-1069-1226)
- Hyun Park (ORCID: https://orcid.org/0000-0002-7825-9165)
- Ajay Goel (ORCID: https://orcid.org/0000-0003-1396-6341)
- Rose Blodgett
Institutions
- Allegheny Health Network (US)
- Cleveland Clinic (US)
- City of Hope (US)
- Beckman Research Institute
Publication Details
- Journal
- Cancers
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3390/cancers17030542
- Citations
- 2
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Allegheny Health Network