Melatonin alleviates senile osteoporosis by regulating autophagy and enhancing fracture healing in aged mice
Our data suggest that the application of MEL can restore degenerative osteogenesis of aged bone marrow-derived mesenchymal stem cells, and has the potential to regain bone mass in aged mice through activating autophagy via the <i>PIK3C-AKT-MTOR</i> pathway. MEL therefore may serve as a potential clinical therapy to treat senile osteoporosis.
Authors
- Xiaoxu Guan (ORCID: https://orcid.org/0000-0002-3286-9769)
- Denghui Zhang (ORCID: https://orcid.org/0000-0002-4429-6275)
- Tianer Zhu
- Yi Zhou (ORCID: https://orcid.org/0000-0001-8330-7363)
- Junru Wen (ORCID: https://orcid.org/0000-0002-9575-2461)
- Jingyao Bai
- Chunchun Chen (ORCID: https://orcid.org/0009-0006-7073-735X)
Institutions
- Stomatology Hospital (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1302/2046-3758.142.bjr-2024-0112.r2
- Citations
- 1
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province