OINTMENT EFFECTIVENESS IN EXPERIMENTAL WOUNDS IN CATTLE

The purpose of research is to study an experimental ointment and its effectiveness in the treatment of mechanical disorders of the integrity of the skin in cattle. Objectives: to study the effectiveness of using an experimental ointment in the treatment of purulent wounds in cattle; to evaluate the local irritant effect of the experimental ointment. The study was carried out from 2018 to 2022 on the basis of the educational and experimental farm Kuban of Kuban State Agrarian University and the Stud Farm of the Krasnodar Educational Farm of Krasnodar State Agrarian University on Holstein-Friesian bull calves aged 12–13 months, weighing 320–340 kg. A total of 2,890 animals were examined. Some of the experiments were carried out at the Department of Anatomy, Veterinary Obstetrics and Surgery, Faculty of Veterinary Medicine, Kuban State Agrarian University named after I.T. Trubilin. When studying the species microflora during purulent inflammation of the udder, limbs and posterior part of the hip area, the following was revealed: if the level of tissue contamination is higher than CFU per 1 g of contents or equal to 105, then it is, accordingly, critical. Exceeding these units indicates that pathogens can spread through the lympho-hematogenous route throughout the body. The object of the study is an ointment based on polyethylene oxide 1500, pork pepsin (powder), sodium salicylate, metronidazole and dioxidine. To study the optimal ratio of the components of the experimental ointment, antimicrobial activity was determined by diffusion into agar. For this purpose, epidermal and Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and fecal enterococcus were used. To study the effect on the microstructure of rat organs, the material was taken after slaughter and left in a 10% solution of neutral formaldehyde.