No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis
Bernaleau et al. (https://doi.org/10.1084/jem.20240825) show that CCDC134 located in the ER is required for TLR biogenesis by controlling the N-glycosylation, folding, and stabilization of the ER chaperone Gp96.
Authors
- Leslie C Domínguez Cadena (ORCID: https://orcid.org/0000-0002-6212-8785)
- Antje Blumenthal (ORCID: https://orcid.org/0000-0003-3673-7015)
Institutions
- The University of Queensland (AU)
Publication Details
- Journal
- The Journal of Experimental Medicine
- Published
- 2025-01-22
- DOI
- https://doi.org/10.1084/jem.20242285
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Research Council
- National Health and Medical Research Council