Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach
A neuropsychological data-driven method to phenotype EOAD individuals uncovered a more detailed understanding of the presenting heterogeneity in this atypical AD sample compared to clinical judgment alone. Clinicians and patients may over-report memory dysfunction at the expense of non-memory symptoms. These findings have important implications for diagnostic accuracy and treatment considerations.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Stephen Salloway (ORCID: https://orcid.org/0000-0002-2631-0942)
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Lea T. Grinberg (ORCID: https://orcid.org/0000-0002-6809-0618)
- Clifford R. Jack (ORCID: https://orcid.org/0000-0001-7916-622X)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Angelina J. Polsinelli (ORCID: https://orcid.org/0000-0002-7738-9574)
- David Clark (ORCID: https://orcid.org/0000-0002-7004-934X)
- Arthur W. Toga (ORCID: https://orcid.org/0000-0001-7902-3755)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Julien Lagarde (ORCID: https://orcid.org/0000-0002-2018-261X)
- Alexander Taurone
- S. J. Wolk (ORCID: https://orcid.org/0000-0002-0826-9261)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-2917-8297)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- Paul S. S Aisen (ORCID: https://orcid.org/0000-0002-2896-5838)
- Sharon Sha
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Deepti Putcha (ORCID: https://orcid.org/0000-0001-5575-5572)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Melissa E. Murray (ORCID: https://orcid.org/0000-0001-7379-2545)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kyle Womack (ORCID: https://orcid.org/0000-0002-6060-9075)
- Laurel Beckett (ORCID: https://orcid.org/0000-0002-2418-9843)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Walter A. Kukull (ORCID: https://orcid.org/0000-0001-8761-9014)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- David Thomas Jones (ORCID: https://orcid.org/0000-0002-4807-9833)
- Kathy L. Newell (ORCID: https://orcid.org/0000-0002-1648-7357)
- Rema Raman (ORCID: https://orcid.org/0000-0002-4096-6390)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Robert A. Koeppe (ORCID: https://orcid.org/0000-0002-9514-5311)
- Ranjan Duara (ORCID: https://orcid.org/0000-0001-8060-6309)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Tatiana M. Foroud
- Neill R. Graff‐Radford
- Kala Kirby
- Bernardino Ghetti
- Maryanne Thangarajah
- Meghan Riddle
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Alzheimer's Association (US)
- Houston Methodist (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- WinnMed (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Mayo Clinic in Arizona (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of San Francisco (US)
- University of Pennsylvania (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s13195-025-01689-8
- Citations
- 6
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 8.83
Funders
- Alzheimer's Association
- Massachusetts General Hospital
- Centre d'Imagerie BioMédicale
- National Institutes of Health
- Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering