UBE2T/CDC42/CD276 signaling axis mediates brain metastasis of triple-negative breast cancer via lysosomal autophagy
In conclusion, our results indicate a new mechanism whereby UBE2T-mediated ubiquitination positively controls the UBE2T/CDC42/CD276 axis to upregulate tumor cell expression of CD276 and thereby impair CD8<sup>+</sup> T cells function, ultimately leading to tumor cell immune escape and BrM.
Authors
- Jun Jun Li (ORCID: https://orcid.org/0000-0001-5591-5396)
- Qian Chen (ORCID: https://orcid.org/0009-0006-2281-0719)
- X. Qiao (ORCID: https://orcid.org/0009-0009-2481-5435)
- Qiao Cheng (ORCID: https://orcid.org/0000-0002-1164-0877)
- Liang Shi (ORCID: https://orcid.org/0000-0001-9551-0641)
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0001-8844-0286)
- Yan Chen (ORCID: https://orcid.org/0000-0002-6630-0693)
- Ming Xie (ORCID: https://orcid.org/0009-0002-2651-1856)
- Jin Yao (ORCID: https://orcid.org/0000-0003-3028-9370)
- Tao Liang (ORCID: https://orcid.org/0000-0002-5980-5503)
- Li Li (ORCID: https://orcid.org/0009-0003-4636-9487)
- Rong Fu (ORCID: https://orcid.org/0000-0002-7342-263X)
- Min Jie Wang
Institutions
- Wuhan Union Hospital (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010782
- Citations
- 13
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 17.60