Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8<sup>+</sup> T-cell antitumor activity via the non-canonical P53/STING pathway
Our study is the first to show that Clo, an FDA-approved drug, induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8<sup>+</sup> T-cell antitumor activity via the non-canonical P53-STING-NF-κB signaling pathway, providing a novel strategy for the clinical therapy of melanoma and lung cancer.
Authors
- Cong Peng (ORCID: https://orcid.org/0000-0001-7104-5490)
- Jie Wu (ORCID: https://orcid.org/0000-0001-5664-599X)
- Q. Li
- Nian Liu (ORCID: https://orcid.org/0000-0002-4108-7937)
- Jing Chen (ORCID: https://orcid.org/0000-0003-1532-3550)
- Xiang Chen (ORCID: https://orcid.org/0000-0001-8187-636X)
- Qian Tao (ORCID: https://orcid.org/0000-0001-8172-7954)
- Can Lu (ORCID: https://orcid.org/0000-0003-0898-1854)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010252
- Citations
- 17
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 13.56
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Higher Education Discipline Innovation Project
- Project 211