Iron/Rhodium Bimetallic Lewis Acid/Transition Metal Relay Catalysis for Alkynylation/Cyclotrimerization Sequential Reactions Toward Isoindolinone Derivatives from N,O-Cyclic Acetals
A novel sequential one-pot bimetallic catalytic system combining Fe(III)-catalyzed alkynylation and a Rh(I)-catalyzed [2+2+2] reaction was successfully developed. The σ-Lewis acid properties of iron (III) and the π-Lewis acid properties of rhodium (I) catalysts were unified in an unprecedented intermolecular alkynylation/cyclotrimerization one-pot process. Using this unique Fe/Rh bimetallic relay catalytic system, a variety of benzo and pyrridinoisoindolinone derivatives were obtained under mild conditions from easily available N-(propargyl) hydroxy aminals, as the simplest N-acyliminium ion precursors, and several alkynes.
Authors
- Abderrahmane Ould Hadou
- Mohamed El‐Shazly (ORCID: https://orcid.org/0000-0003-0050-8288)
- Ewies F. Ewies (ORCID: https://orcid.org/0000-0002-4832-5766)
- Adam Daı̈ch (ORCID: https://orcid.org/0000-0002-6942-0519)
- Sidi Mohamed Abdallahi
- Brahim Ould Elemine (ORCID: https://orcid.org/0000-0002-5057-9829)
- Ata Martin Lawson (ORCID: https://orcid.org/0000-0002-1641-4190)
- Mohamed Othman (ORCID: https://orcid.org/0000-0002-8379-5704)
Institutions
- Ain Shams University (EG)
- Centre National de la Recherche Scientifique (FR)
- Université Le Havre Normandie (FR)
- Normandie Université (FR)
- National Research Centre (EG)
- Unité de Recherche en Chimie Organique et Macromoléculaire (FR)
- Université de Nouakchott (MR)
Publication Details
- Journal
- Catalysts
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3390/catal15020151
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Centre
- Science and Technology Development Fund
- Campus France
- Région Normandie