Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility
These results collectively demonstrate that cytokinesis failure mediates cardiomyocyte multinucleation and cell cycle exit of postnatal cardiomyocytes, but may be a protective mechanism to preserve the contractile function of the myocardium.
Authors
- Yan Liu (ORCID: https://orcid.org/0000-0002-8314-985X)
- Ivan Menendez-Montes
- Ngoc Uyen Nhi Nguyen (ORCID: https://orcid.org/0000-0003-0694-3176)
- N Briard
- Waleed M. Elhelaly (ORCID: https://orcid.org/0000-0002-6942-3680)
- Ching-Cheng Hsu
- Nicholas T. Lam (ORCID: https://orcid.org/0000-0002-9446-7378)
- Hesham A. Sadek (ORCID: https://orcid.org/0000-0002-4745-366X)
- Feng Xiao (ORCID: https://orcid.org/0000-0002-9084-9328)
- Alisson C. Cardoso (ORCID: https://orcid.org/0000-0002-3051-9976)
- Lior Zangi (ORCID: https://orcid.org/0000-0002-6153-9857)
- Shah Raj Ali (ORCID: https://orcid.org/0000-0002-1241-6826)
- Nguyen-Phong Vo (ORCID: https://orcid.org/0000-0003-1051-5107)
- Suwannee Thet
- Chao Xing (ORCID: https://orcid.org/0000-0002-1838-0502)
- Mahmoud S. Ahmed (ORCID: https://orcid.org/0000-0002-5600-4698)
- Shujuan Li (ORCID: https://orcid.org/0000-0001-9792-790X)
- Lobna El-Feky
- Qamar M. Omari
Institutions
- United States Nuclear Regulatory Commission (US)
- University of Arizona (US)
- The Heart Research Institute (AU)
- Southwestern Medical Center (US)
- Centro Nacional de Epidemiología (ES)
- Anna Needs Neuroblastoma Answers (US)
- McDermott International (United States) (US)
- Center for Neuroscience and Regenerative Medicine (US)
- The University of Texas Southwestern Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1161/circulationaha.124.065763
- Citations
- 6
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 4.84