Loss of Endothelial TRPC1 Induces Aortic Hypercontractility and Hypertension
Our results identify endothelial TRPC1 as a previously unclear regulator of vascular changes and blood pressure in both physiological and pathologically obese state, and it is associated with nitric oxide/endothelin-1/c-Fos signaling.
Authors
- Yifei Zhu (ORCID: https://orcid.org/0000-0003-4352-6507)
- Yingxia Lan (ORCID: https://orcid.org/0000-0001-9753-9149)
- Yuan Chu (ORCID: https://orcid.org/0000-0003-2158-305X)
- Xin Ma (ORCID: https://orcid.org/0000-0001-8525-068X)
- Xianfeng Wang (ORCID: https://orcid.org/0000-0002-7760-6647)
- Sheng Wang (ORCID: https://orcid.org/0000-0003-2696-2171)
- Yizhi Zhang (ORCID: https://orcid.org/0009-0000-5586-5886)
- Yu Fan
- Yuan Liu (ORCID: https://orcid.org/0000-0002-6326-1270)
Institutions
- Jiangnan University (CN)
- World Wide Web Consortium (US)
- Wuxi Fourth People's Hospital (CN)
- State Key Laboratory of Food Science and Technology (CN)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1161/circresaha.124.325574
- Citations
- 4
- Primary Topic
- Ion Channels and Receptors
- Type
- article
- Field-Weighted Citation Impact
- 5.86