Adjusted polygenic risk score: A novel biomarker for the prevention of cardiovascular diseases

Accurate risk assessment is crucial for effective cardiovascular disease (CVD) prevention.Traditional methods often underestimate the risk, particularly in those with genetic predisposition.The present study introduces a novel approach integrating polygenic risk scores (PRS) with lifestyle factors in an aim to enhance risk assessment.Buccal swab samples from 287 healthy individuals (utilizing only pre-existing anonymized genetic data) were used to calculate PRS and adjusted PRS (Adj-PRS).The analysis revealed significant associations between PRS, Adj-PRS and cardiovascular risk factors.In a separate cohort of 291 individuals, significant associations were demonstrated between Adj-PRS and hypertension, body mass index, salt consumption, exercise levels, and smoking status.Overall, the findings presented herein highlight the utility of PRS and Adj-PRS in refining cardiovascular risk assessment and identifying individuals who are at an increased risk of developing CVD and who may benefit from targeted preventive interventions.This novel approach has implications for personalized medicine and may contribute to more effective CVD prevention strategies in clinical practice.