Bidirectional Association of Gut Microbiota-Derived Trimethylamine N-Oxide and its Precursors with Estimated Glomerular Filtration Rate: A Cross-Lagged Cohort Study
Deceased eGFR is related to elevated serum carnitine concentrations and may be linked to choline. Conversely, elevated TMAO may be linked to reduced kidney function. This provides novel evidence that managing healthy kidney function helps keep TMAO and its precursors at optimal levels, whereas maintaining low TMAO concentrations reduces risk of kidney disease.
Authors
- Bin Liang (ORCID: https://orcid.org/0000-0002-7592-5484)
- Enmao Cai
- Wenli Ruan
- Ying Lü (ORCID: https://orcid.org/0000-0002-7698-8962)
- Mingfeng Ma
- Ruiheng Peng (ORCID: https://orcid.org/0000-0001-7593-6143)
- Yani Wu (ORCID: https://orcid.org/0009-0006-3664-8791)
- Liqiang Zheng (ORCID: https://orcid.org/0000-0003-0101-9398)
- He Bai
- Xiaohong Zhang (ORCID: https://orcid.org/0000-0003-4435-8357)
- Peiying Tian
Institutions
- Shanxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Pudong Medical Center (CN)
- Second Hospital of Shanxi Medical University (CN)
- Shanxi Fenyang Hospital (CN)
- Shanghai Children's Hospital (CN)
- Shanghai Municipal Center For Disease Control Prevention (CN)
Publication Details
- Journal
- Journal of Nutrition
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.tjnut.2025.02.002
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China