Development and validation of a time-varying correction factor for QT interval assessment in drug-resistant tuberculosis patients
The time-varying CF effectively captures the dynamic QT-HR relationship during TB treatment, reducing the risk of misdiagnosing QT prolongation or unnecessary discontinuation of treatment. By addressing underestimation and overestimation issues in QT interval assessment, this method enhances drug evaluation in clinical trials and supports improved treatment decisions for TB patients.
Authors
- Kelly E. Dooley (ORCID: https://orcid.org/0000-0001-9013-5256)
- Graeme Meintjes (ORCID: https://orcid.org/0000-0003-1196-4414)
- Elin M. Svensson (ORCID: https://orcid.org/0000-0002-0093-6445)
- Gary Maartens (ORCID: https://orcid.org/0000-0003-3080-6606)
- Bart Remmerie (ORCID: https://orcid.org/0000-0003-1775-4194)
- Anne‐Gaëlle Dosne
- Mats O. Karlsson (ORCID: https://orcid.org/0000-0003-1258-8297)
- James C.M. Brust
- Thanakorn Vongjarudech (ORCID: https://orcid.org/0009-0001-1335-1366)
Institutions
- Uppsala University (SE)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- Janssen (Belgium) (BE)
- Radboud University Nijmegen (NL)
- University of Cape Town (ZA)
- Radboud University Medical Center (NL)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- International Journal of Antimicrobial Agents
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.ijantimicag.2025.107460
- Citations
- 5
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- City University of New York
- Wellcome Trust
- ViiV Healthcare
- ACT Government
- Vetenskapsrådet
- National Institutes of Health
- Uppsala Multidisciplinary Center for Advanced Computational Science
- National Institute of Allergy and Infectious Diseases
- Janssen Pharmaceuticals
- Einstein-Rockefeller-CUNY Center for AIDS Research, Albert Einstein College of Medicine