The absolute number of circulating Treg cells is reduced in difficult-to-treat RA patients and is ameliorated by low-dose IL-2
The number of lymphocytes and subsets in D2T RA patients was reduced, especially Treg cells, resulting in a shift in the balance of effector T cells/Treg cells toward effector T cells, which is ameliorated by low-dose IL-2 without obvious side effects.
Authors
- Xiaoyu Zi
- Caihong Wang (ORCID: https://orcid.org/0000-0002-6808-3709)
- Chong Gao (ORCID: https://orcid.org/0000-0001-7639-0808)
- Huer Yan
- Huanhuan Yan (ORCID: https://orcid.org/0000-0002-0095-6307)
- Xiaofeng Li (ORCID: https://orcid.org/0000-0002-3888-6359)
- Xiaoying Zhang (ORCID: https://orcid.org/0000-0002-8130-1889)
- Jie Bai (ORCID: https://orcid.org/0000-0002-0112-4940)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Shanxi Medical University (CN)
- Shanxi University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1522893
- Citations
- 2
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China