BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice
In summary, our findings demonstrate that combining BCG vaccination with B cell targeted immunomodulatory therapies can improve long-term protection against pulmonary tuberculosis, highlighting the continued relevance and underutilized potential of BCG as a vaccine platform.
Authors
- Maureen Dougher
- Rosleine Antilus-Sainte
- Martin Gengenbacher (ORCID: https://orcid.org/0000-0002-0208-5920)
- Chen-Yu Tsai
- Min Xie (ORCID: https://orcid.org/0000-0002-9770-5351)
- Joshua Woo (ORCID: https://orcid.org/0000-0002-2849-2604)
- Melissa Cristaldo
- Narineh M. Odjourian
- Frank Nuritdinov
Institutions
- Hackensack Meridian Health (US)
- Center for Discovery (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1551183
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases