Decreased energy production and Ca2+ homeostasis imbalance induce myocardial hypertrophy in PDHA1-deficient human pluripotent stem cell derived cardiomyocytes
Elevated diastolic Ca<sup>2+</sup> resulting from reduced energy production and lactate accumulation can trigger overactivation of the calcium signaling pathway, diastolic dysfunction, mitochondrial damage, which constitutes the core pathogenic mechanism of myocardial hypertrophy in KO iPSC-CMs.
Authors
- Mengduan Liu
- Ningyu Ding
- Hailong Tao (ORCID: https://orcid.org/0000-0002-6796-6702)
- Jianzeng Dong (ORCID: https://orcid.org/0000-0001-7299-7805)
- Yangyang Liu (ORCID: https://orcid.org/0000-0001-8296-7095)
- Jihong Sun (ORCID: https://orcid.org/0009-0000-2058-2675)
- Xiaoyan Zhao (ORCID: https://orcid.org/0000-0003-2468-6767)
- Chongpei Hua
- Xiaowei Li (ORCID: https://orcid.org/0009-0005-9996-1999)
- Jianchao Zhang
Institutions
- Beijing Anzhen Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.lfs.2025.123439
- Citations
- 2
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Henan Provincial Science and Technology Research Project