Aldh1l1‐Cre/ERT2 Drives Flox‐Mediated Recombination in Peripheral and CNS Infiltrating Immune Cells in Addition to Astrocytes During CNS Autoimmune Disease
Use of Aldh1l1-Cre/ERT2 should therefore account for recombination in both astrocytes and immune cells in disease models involving peripheral immune cell infiltration into the CNS.
Authors
- Joseph F. Weiss
- Juan Turati (ORCID: https://orcid.org/0000-0003-3817-0489)
- Mario Amatruda (ORCID: https://orcid.org/0000-0002-5407-238X)
- Sam Horng (ORCID: https://orcid.org/0000-0001-5391-9000)
- Graham J. Britton (ORCID: https://orcid.org/0000-0003-4630-1223)
- Zhihong Chen (ORCID: https://orcid.org/0000-0001-7403-7015)
- Jorge Villavicencio (ORCID: https://orcid.org/0009-0001-1246-2857)
Institutions
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/brb3.70239
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Multiple Sclerosis Society
- Conrad N. Hilton Foundation
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke