Carboxyaminotriazole: A bone savior in collagen-induced arthritis—Halting osteoclastogenesis via interleukin-1β downregulation
CAI may have therapeutic value in treating RA-related bone erosion, likely due to its inhibition of overactive osteoclasts by suppressing the NF-κB/MAPK pathways and the subsequent expression of IL-1β.
Authors
- Shan Lu
- Lei Zhu (ORCID: https://orcid.org/0000-0003-3471-1663)
- Mei Yang (ORCID: https://orcid.org/0000-0002-0376-6592)
- Juan Li (ORCID: https://orcid.org/0000-0002-2140-1845)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.lfs.2025.123440
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81