Retinal and Choriocapillaris Thickness Changes in Spontaneously Diabetic Macaques
Consistent with humans, early diabetes in cynomolgus macaques results in notable alterations in retinal thickness, particularly affecting the nasal inner retina. The observed increase in choriocapillaris thickness in both diabetic macaques and human patients with NPDR likely indicates pathologic changes and remodeling due to diabetes. Cynomolgus macaque presents a valuable NHP model for studying diabetic retinopathy.
Authors
- Lingli Zhou (ORCID: https://orcid.org/0000-0002-9321-9348)
- Elia J. Duh (ORCID: https://orcid.org/0000-0003-1917-373X)
- Charles G. Eberhart (ORCID: https://orcid.org/0000-0002-2910-9427)
- Kaoru Ri (ORCID: https://orcid.org/0009-0004-9315-1912)
- Xialin Liu (ORCID: https://orcid.org/0000-0003-2086-5805)
- Xiangrong Kong (ORCID: https://orcid.org/0000-0001-9170-983X)
- Amir H. Kashani (ORCID: https://orcid.org/0000-0001-9767-7920)
- Wei Yi (ORCID: https://orcid.org/0000-0001-7936-9326)
- Wenqing Zhang (ORCID: https://orcid.org/0000-0002-3636-7133)
- Haining Lu (ORCID: https://orcid.org/0000-0001-5209-8669)
- Zhenhua Xu (ORCID: https://orcid.org/0000-0002-9279-0147)
- Shuxin Fan
Institutions
- Johns Hopkins University (US)
- Sun Yat-sen University (CN)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1167/iovs.66.2.11
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Research to Prevent Blindness
- National Institutes of Health
- Guangzhou Municipal Science and Technology Project