Effect of host telomerase inhibition on human cytomegalovirus
Human cytomegalovirus (HCMV) seroprevalence and morbidity in immunocompromised patients and neonates infected <i>in utero</i> remain high globally. Host telomerase has been implicated in the success of multiple infection-induced pathologies, including the success of both lytic infection and oncogenesis in certain herpesviruses. The results of this study suggest a similar biologically important role for host telomerase in lytic HCMV infection. Furthermore, these results may provide the potential for a novel, adjunctive anti-viral treatment for HCMV infection as well as insight into the viral products likely to be involved with HCMV regulation of telomerase.
Authors
- Maciej T. Nogalski (ORCID: https://orcid.org/0000-0001-5095-7570)
- Sherry Zhang
- Cora N. Betsinger (ORCID: https://orcid.org/0000-0001-9263-3873)
- Nicole Katchur (ORCID: https://orcid.org/0000-0002-3936-1917)
- Ileana M. Cristea (ORCID: https://orcid.org/0000-0002-6533-2458)
- Daniel A. Notterman (ORCID: https://orcid.org/0000-0002-8809-8297)
- Kun Yang (ORCID: https://orcid.org/0000-0001-8198-132X)
- Chloe M. Cavanaugh (ORCID: https://orcid.org/0000-0002-2560-210X)
Institutions
- Princeton University (US)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-02-05
- DOI
- https://doi.org/10.1128/jvi.01578-24
- Citations
- 2
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- New Jersey Health Foundation
- National Institutes of Health
- Stand Up To Cancer
- National Institute of General Medical Sciences
- National Institute of Allergy and Infectious Diseases
- National Institute of Child Health and Human Development
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development