Virtual Screening, Toxicity Evaluation and Pharmacokinetics of Erythrina Alkaloids as Acetylcholinesterase Inhibitor Candidates from Natural Products
8-Oxoerythmelanthine (<b>128</b>) exhibits strong potential as an AChE inhibitor with a favorable balance of efficacy, safety, and pharmacokinetic properties. These results warrant further investigation in preclinical and clinical studies to validate its therapeutic potential and safety for Alzheimer's disease treatment.
Authors
- Jalifah Latip (ORCID: https://orcid.org/0000-0002-9214-1251)
- Ari Hardianto (ORCID: https://orcid.org/0000-0001-6065-5437)
- Abd. Wahid Rizaldi Akili (ORCID: https://orcid.org/0009-0003-1830-1389)
- Tati Herlina (ORCID: https://orcid.org/0000-0003-0007-8695)
- Allyn Pramudya Sulaeman (ORCID: https://orcid.org/0000-0001-8977-2485)
- Afri Permana
Institutions
- National University of Malaysia (MY)
- Padjadjaran University (ID)
Publication Details
- Journal
- Advances and Applications in Bioinformatics and Chemistry
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/aabc.s495947
- Citations
- 4
- Primary Topic
- Cholinesterase and Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Lembaga Pengelola Dana Pendidikan
- Universitas Padjadjaran