The risk of osteonecrosis after apical patency during antiresorptive therapy in an animal model
Apical patency in rats treated with zoledronic acid or denosumab did not cause osteonecrosis of the jaw, only micro-CT changes in bone microarchitecture that cannot be linked to osteonecrosis in zoledronic acid treated animals.
Authors
- Clara de Figueiredo Lopes
- Karem Paula Pinto (ORCID: https://orcid.org/0000-0001-5642-9541)
- Jenif Braga de Souza (ORCID: https://orcid.org/0000-0003-0174-6042)
- Erick Miranda Souza (ORCID: https://orcid.org/0000-0003-2074-0834)
- Emmanuel João Nogueira Leal Silva (ORCID: https://orcid.org/0000-0002-6445-8243)
- Luciana Moura Sassone (ORCID: https://orcid.org/0000-0002-6181-7490)
- Adriana Terezinha Neves Novellino Alves (ORCID: https://orcid.org/0000-0002-3665-6568)
- Ricardo Tadeu Lopes
- Cláudio Malizia Alves Ferreira (ORCID: https://orcid.org/0000-0002-4970-3757)
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Universidade Federal Fluminense (BR)
- Universidade Unigranrio (BR)
- Universidade do Estado do Rio de Janeiro (BR)
- Universidade Federal do Maranhão (BR)
Publication Details
- Journal
- International Endodontic Journal
- Published
- 2025-02-04
- DOI
- https://doi.org/10.1111/iej.14207
- Citations
- 2
- Primary Topic
- Bone health and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro